Nutriment – Minerals

### Other MINERALS :

## Food Mineral levels Declining,

Older people often comment that food does not taste as good as they remember when they were little and there could be good reason for it, as the food we grow is definitely not the same as it was.

It has been previously noted that the nutrients in food seem to be reducing, but the latest figures are very alarming with some cuts of meat for example, containing as much as 54% less iron now, than they did in 1940.

A primary healthcare practitioner, Dr David Thomas, made a comparison of government tables published in 1940 and again in 2002. He concentrated on 27 varieties of vegetables, 17 varieties of fruit and 10 cuts of meat, and found huge losses in mineral content across the board.

He also found that dairy foods have as much as 90% less copper and that Parmesan cheese in particular, contained 70% less calcium, the latter a potential indication of increasing rates of osteoporosis.

Dr Thomas put it down largely to intensive farming on exhausted land, but also cited the use of varieties that were selected more for ease of growing rather than nutrition.The figures did not even take into account the processing that food can now go through before it reaches your plate, as this can deplete the nutritional content still further. Along with the greater need for some nutrients due to the modern lifestyle, this could spell disaster for future generations, if not the current one, as deficiency states become the norm.



## Dietary Chromium: An Overview, By Barry Mennen, M.D.,

Executive Director, Chromium Information Bureau, Inc.

# Definition and Function:

Chromium is an element; that is, it is one of the basic building blocks of all things, both living and non-living. And, like certain of the elements such as carbon, nitrogen, iron and calcium (among others), chromium plays an essential role in our life and health.

Chromium’s function in our bodies is critical: without it, the hormone insulin would not work.

Most people are familiar with insulin as the shot diabetics give themselves in order to control their high blood sugar. But, what most people don’t realize is that insulin is the “master hormone” of our metabolism; it not only controls blood sugar levels and many other aspects of carbohydrate breakdown and storage, but also directs much of the metabolism involving fat, protein and energy (calories).

Because insulin requires chromium to function properly, this trace element has significant biological effects in the body. (See below for more on insulin)

# Chemistry: Trivalent and Hexavalent Chromium

The chromium that our bodies require is called trivalent chromium, which means it has a net electronic charge ( the major determinant of how it will react chemically with other molecules) of plus three (3+). The precise way in which trivalent chromium (symbolically written as Cr3+) affects insulin’s actions is not presently known but is under active investigation.

There is another type of molecular chromium with a valence of six (Cr6+ or hexavalent chromium), which unlike trivalent chromium, does not occur naturally in significant amounts. Hexavalent chromium forms as a byproduct of certain industrial processes (such as the making of stainless and hard-alloy steels and in the manufacture of certain pigments; the name chromium comes from the Greek word for color).

Hexavalent chromium has been shown to be carcinogenic; however, it is important to understand that the cancer-causing potential of hexavalent chromium has nothing whatsoever to do with dietary or trivalent chromium; there are many other examples of different molecular forms of the same substance having completely distinct chemical and/or biochemical properties (oxygen and iron come readily to mind).

Trivalent chromium has been tested over several decades and has never been shown to cause cancer in any animal ever studied. And, it should be noted that trivalent chromium cannot change into hexavalent chromium inside the body.

(Also, please see Safety section below)

# Discovery of Chromium’s Role in Human Health

It was known by the 1950s that chromium was required by animals to control blood sugar, but it wasn’t until the 1970s that chromium’s essential role in humans was clearly proven. This proof came accidentally, as a result of a new procedure that had been introduced to nourish hospitalized patients who could not take in any food by mouth. This procedure, giving specially made feeding solutions directly through the patient’s vein, is referred to as Total Parenteral Nutrition or TPN.

TPN was designed to give patients all the carbohydrates, proteins, fats, vitamins and minerals they needed to maintain health until they could once again eat normally and obtain these nutrients from food. Some of these patients who had been fed intravenously for months developed high blood sugars just as if they were diabetic (which they weren’t). The doctors then had to start insulin therapy in order to treat this diabetes-like condition and even then the insulin they were given didn’t appear to work as well as it should have.

Since it was already known that chromium was necessary for insulin action, it was thought that this trace element may have been lacking in these patients’ TPN solutions. Thus it was deduced that these patients were showing signs of very severe chromium deficiency. The physicians caring for them then added chromium in very small amounts less than 50 micrograms (abbreviated as mcg; equal to 1/1000 of a milligram) to their IV feeding solution and quickly noted an improvement.

The patients no longer required insulin injections, and their blood sugars and other abnormalities returned to normal. After these cases of chromium deficiency and its serious consequences were reported, medical and nutrition experts agreed that chromium was an essential nutrient for humans and advised health professionals administering TPN about the danger of omitting chromium from the solutions.

Both the Food and Drug Administration (FDA) and the Food and Nutrition Board of the National Research Council (the quasi-governmental body that determines the Recommended Dietary Allowances or RDAs ) have therefore designated chromium an essential nutritional trace element.

Although insulin mainly works in muscle, fat and the liver, this hormone also exerts profound effects on many other body tissues. Insulin is the primary hormone that controls how the body’s cells absorb, use and store nutrients and energy. Besides regulating the cellular absorption and utilization of glucose, amino acids (the building blocks of protein) and fatty acids, insulin also activates and inactivates enzymes (the protein catalysts for the body’s biochemical reactions) and directly affects certain genetic processes including protein synthesis.

While trivalent chromium works with insulin to move glucose into cells, we currently do not know how many other critical actions of insulin require chromium to function. However, regarding the insulin-induced movement of glucose into cells, it is likely that chromium is either involved with the binding of insulin to its receptor (the site on the cell membrane which responds to signals from biochemical messengers such as hormones, drugs and nutrients and then stimulates or inhibits specific cellular functions) or with certain of the reactions which take place after the initial receptor site activation, reactions that are referred to as post-receptor events.

# Chromium and Diabetes

Because of chromium’s connection to insulin function, it should come as no surprise that most of the research with this trace mineral relates to diabetes or to non-diabetic persons who develop high blood glucose levels after ingesting simple sugar. There are at least 16 clinical studies, which have tested specific chromium compounds in such patients using proper scientific methods (other studies on chromium supplementation in diabetics which used questionable methods in their study design are not included in the following summary).

While three of the 17 properly designed studies showed no benefit of chromium supplementation in diabetics, 14 did show blood glucose improvements in the patients tested. For example, a recent study that has been reported (which was presented in 1995 at the annual meeting of the American College of Nutrition) showed dramatic improvements in blood sugar using less than one milligram of supplemental chromium picolinate in a group of women who developed gestational diabetes (that is, they showed symptoms and signs of diabetes only during their pregnancies).

The latest study to examine the issue of chromium supplementation and adult-onset diabetes was presented in June, 1996 at the annual Scientific Sessions of the American Diabetes Association held in San Francisco, CA. Researchers from the Human Nutrition Research Center of the United States Department of Agriculture collaborated with Chinese researchers from the Beijing Medical University.

They randomized 180 adult-onset diabetics into 3 groups of 60 each: one group received placebo twice per day, the second received 100 mcg twice daily of chromium as chromium picolinate and the third received 500 mcg of chromium as chromium picolinate twice daily. Their blood work was examined at baseline, at 2 months and at 4 months.

The patients were told to remain on their anti-diabetic medications and continue with their diets and activity levels as before.

The results were impressive: blood glucose, insulin levels, cholesterol and glycated hemoglobin (a measure of blood sugar control over the previous few months) all decreased, with the higher dose generally (but not always) more effective than the 200 mcg.

How could such tiny amounts of chromium have such profound effects on insulin’s action? Again, the answer is not known with certainty, but the evidence so far suggests that chromium strengthens certain effects of insulin on the body’s cells; in other words, it doesn’t work by stimulating the body to make more insulin, but rather chromium makes the insulin, which is present function more effectively in the cells of the body.

When the body does not respond to insulin in the normal manner, doctors refer to this as insulin resistance. Insulin resistance signifies that the insulin, which is circulating in the blood, is not able to have its usual effects on various tissues in the body. This is not the problem with the type of diabetes (referred to as type I or juvenile-onset) that strikes young children: these individuals cannot make insulin anymore and thus must take it by injection. However, most diabetics suffer from maturity-onset diabetes (or type II; increasingly referred to as NIDDM or non-insulin dependent diabetes mellitus; this type of diabetes affects 90% of people with the disease).

It is these patients with NIDDM who demonstrate insulin resistance and are the ones most at risk for chromium deficiency and its consequences. Further, there is some evidence that marginal chromium deficiency may be important in other areas of health and disease. These other diseases where chromium may be important are some of the most common and significant illnesses of industrialized nations (see below).

The following is the ending to the chapter on chromium nutrition in the latest edition of the standard reference textbook on medical nutrition:

“Based on current knowledge of chromium function and nutrition, the possibility cannot be ignored that inadequate chromium status may be responsible in part for some cases of impaired glucose tolerance, ‘hyperglycemia, hypoglycemia. glycosuria [sugar in urine], and refractoriness to insulin.”

Modern Nutrition in Health and Disease, Eighth Ed.., 1994. Shils, Olson and Shike, eds.

It is important to note that persons with diabetes who are on insulin or other anti-diabetic medications should check with their doctors before supplementing their diets. Because chromium may decrease the amount of insulin resistance present, it may change the type or amount of medication needed to treat the diabetes and/or the frequency with which blood sugar monitoring needs to be done.

This is especially important for those persons with diabetes who are under tight blood glucose control. Adding supplemental chromium in this situation has the potential to cause low blood sugar (hypoglycemia).

# The Insulin Resistance Syndrome (Syndrome X; Reaven’s Syndrome; Insulin-Metabolic Syndrome):

The combination of obesity, diabetes, hypertension (high blood pressure) along with abnormalities in blood cholesterol and fat (lipid) has long been noted in the medical literature. By the late 1980s, a noted diabetes expert from Stanford University (Dr. Gerald Reaven) proposed that the basic combination of high blood sugar, high blood pressure and abnormal blood lipids all constituted disease that was based on increased insulin resistance; he noted that while increased insulin resistance is the first step in the development of maturity-onset or type II diabetes, it is the body’s response to the insulin resistance which determines whether or not the individual becomes a diabetic or not.

“Even if high blood sugar does not develop, insulin resistance does not appear to be a good thing to have: The fact that an insulin-resistant subject may not become diabetic does not mean that they suffer no untoward consequences. Indeed, an argument can be made that the more insulin sensitive an individual, the better off he or she is, and that the attempt to compensate for insulin resistance sets in motion a series of events that play an important role in the development of both hypertension and coronary artery disease.”

Reaven GM. Role of Insulin Resistance in Human Disease. Diabetes, 37:1595, Dec., 1988.

Since chromium reduces insulin resistance, this essential trace element could therefore have wide-ranging effects on high blood pressure and abnormal blood lipids in addition to lowering blood sugar.

However, Dr. Reaven did not connect any insulin resistance to possible marginal chromium status, and we cite him here only to point out his contribution to describing this syndrome. It is also important to note that while studies in peer-reviewed medical journals have shown that chromium supplementation lowers blood lipids such as triglycerides, for now there are no human data on chromium and blood pressure.

# Chromium and Body Composition

Another area that is gaining more interest lately is the possible effect of chromium on body composition; that is, how chromium affects the relative amounts of lean body mass (mainly muscle) compared to the amount of body fat. At present, there are positive results from studies with four separate animal species supplemented with chromium picolinate: pigs, lambs, rats and chickens. In all of these species, there were increases in muscle mass and decreases in fat body mass. And, in the case of pigs, these findings have been confirmed by several additional studies.

For humans, however, the evidence was not as clear until quite recently. In October, 1996 a study published in a peer-reviewed medical journal looked at 154 slightly overweight individuals split into three groups who were supplemented with either 200 mcg of chromium as the picolinate compound, 400 mcg of chromium as the picolinate compound or a placebo.

Previously, some human studies had shown either no effect, an effect similar to that seen in animals (that is, reduction in fat and increase in muscle) or an effect in women but not in men. The main problem with these older studies was that they had looked at very few individuals sometimes as few as 12; so, while it appeared that chromium was having an effect on body composition, since there were so few persons involved in the studies we could not be absolutely certain.

Further, some of the prior studies looked at young athletes (such as college football players) who, because of their high degree of fitness upon entering the study would not, in all likelihood, make the best subjects in which to observe these changes.

This latest study examined average Americans in Texas who were given no special instructions in diet or exercise just the chromium at either dosage level or the placebo. The study was double blind and randomized. What these researchers found after the 72 days of the study was a statistically significant difference in the chromium groups vs. the placebo group in change of body composition index (BCI, a sum of the loss in body fat plus the gain in muscle mass) loss of body fat and total weight loss.

# The authors conclude:

These data suggest that supplementation with chromium picolinate can lead to significant improvements in body composition when a BCI [body composition index] is used as the outcome criterion that represents a sum of the net gains in nonfat mass added to the sum of the net losses of body fat.

( See What’s A Picolinate? )

Kaats GR, Blum K, Fisher JA and Adelman JA. Effects of chromium picolinate supplementation on body composition: A randomized, double-masked, placebo-controlled study. Current Therapeutic Research, 57(10):747-765, Oct. 1996

While the mechanism of action whereby chromium has this apparent effect is not known, it is interesting to note that therapies for diabetes that increase insulin levels in the blood are associated with weight gain (insulin injections and sulfonylureas such as Diabinese and Micronase) while therapies that decrease insulin levels (such as Glucophage and the not-yet-released oral agent troglitazone) are associated with no weight gain or even weight loss.

Since chromium supplementation has been associated with decreased insulin levels, it is tempting to speculate that it is through this effect (that is, decreasing insulin resistance with the attendant drop in circulating insulin) that chromium works in altering body composition.

# Dietary Intake of Chromium

Data from U. S. Government sources show that the great majority of Americans get less chromium in their daily diets than the amount recommended by nutrition experts (the RDA Committee recommends 50-200 mcg of chromium/day; the vast majority of Americans get less than 50 mcg/day).

“In the majority of all chromium supplementation studies in the United States, at least half the subjects with impaired glucose tolerance improved upon chromium supplementation, suggesting that the lower ranges of chromium intake from typical U.S. diet are not optimal with regard to chromium nutriture.”

RDA 10th Edition 1989

Few foods are rich sources of chromium in the Western diet, the best being organ meats, mushrooms, wheat germ, broccoli and processed meats. It is theorized that Stone Age people ingested more chromium than modern people because they regularly ate organ meats from the animals they hunted (which contained higher levels chromium as well as other trace elements).

Not only did these early people likely have a higher chromium intake than modern ones, but perhaps more important than their higher intakes, it is most likely that they lost less chromium in their urine than we do. This is because Stone Agers did not ingest nearly as much simple sugars as modern people and simple sugar intake causes chromium to be lost in the urine. These ingested sugars (such as table sugar and products made with it) bring insulin and chromium into the blood and cause chromium to be excreted in the urine after it’s through working with the insulin on the increase in blood sugar.

We Americans consume an average of 120 pounds of sugar per year from all sources. Thus, we can conclude that for hundreds of thousands of years of human evolution, our ancestors most likely took in more and lost less of this essential trace element than modern Americans.

Another interesting fact demonstrated in large numbers of people both in the U.S. and the U.K.–is that chromium tissue levels in humans decrease over our lifetimes. In fact, the highest tissue levels of chromium are found in newborns: they get chromium in the womb across the placenta from their mothers. There is also evidence that pregnancy depletes a woman’s chromium stores, which may be one reason that as a total population our bodies show loss of chromium as we age.

From this evidence inadequate chromium intake, increased chromium losses, decreasing chromium tissue levels as we age, improvement in blood sugar in significant numbers of diabetics and pre-diabetics with modest chromium supplementation and widespread insulin resistance (25% of Americans have some degree of insulin resistance, though only a portion of this insulin malfunction appears to be due to chromium deficiency) experts in chromium nutrition urge supplementation with small amounts of this trace element on a daily basis.

These experts feel that chromium supplementation for diabetics should take its place alongside the two other proven ways of decreasing insulin resistance: low-fat, high complex-carbohydrate diets for weight loss/weight maintenance and regular exercise.

# Safety

It is extremely difficult to poison laboratory animals with oral chromium. For example, cats fed 1,000 mg of trivalent chromium per day showed no signs of toxicity (the equivalent daily dose for a 150 lb person would be approximately 35,000 mg per day or 3.5 million mcg per day. In terms of the number of 200 mcg tablets, this would be 175,000 tablets per day for a human.

On March 14, 1996, a safety study conducted by the U. S. Department of Agriculture was presented at the Society of Toxicology’s annual meeting. This study looked at various supplemental doses (including none) of chromium chloride and chromium picolinate fed to rats for 6 months, The highest doses were equal to a human consuming 5,000 tablets of 200 micrograms chromium picolinate. At regular intervals during the study the rats were weighed and blood was taken for laboratory tests.

At the end of the study the livers and kidneys (organs that would have the highest tissue levels of chromium) were examined under the microscope. There were no differences in any of the measurements or examinations between the various groups. The investigators were unaware (“blinded”) as to which group the animals were in when the measurements and evaluations were performed.

The safety issue had been raised by a study published in December 1995, which attempted to link chromosomal damage in the test tube to oral supplementation of chromium picolinate. These researchers used cultured Chinese hamster ovarian cancer cells to which they directly added unnaturally high amounts of chromium compounds, including chromium picolinate. Some of these cells showed chromosomal damage (clastogenic effects).

This was not particularly surprising, since this concentration directly applied to these cells in a test tube was 3,000 times the blood level of people who are ingesting chromium picolinate as supplements!

Very few essential minerals tested in this way would be found to be without toxicity; for example, merely doubling the blood concentration of the mineral calcium is fatal to humans. When tested by the Ames test (a specific test for mutagenicity) for cancer-causing potential, chromium picolinate was proven negative.

Again, the standard medical reference on nutrition:

Trivalent chromium has such a low order of toxicity that deleterious effects from excessive intake of this form of chromium do not occur readily. Trivalent chromium becomes toxic only at extremely high amounts.- chromium then acts as a gastric irritant rather than as a toxic element interfering with essential metabolism or biochemistry.”

Modern Nutrition In Health and Disease, Eighth Ed., 1994. Shils, Olson and Shike, eds.

# Assessment of Chromium Status

One of the main problems that has hindered a more widespread interest and possible usage of chromium by the medical profession is the fact that gauging whether or not someone is chromium deficient or not cannot easily be done. The only generally accepted method for assessment of chromium status is to supplement an individual (who has abnormalities of either blood sugar, cholesterol, triglycerides or all three) with the trace clement and see if the laboratory values improve. If they do, then chromium insufficiency is presumed. This is an expensive and cumbersome process (especially when doing a glucose tolerance test).

# Summary

Indications are that marginal deficiency of chromium, an essential trace mineral, may be widespread in industrialized nations. Further, the consequences of this deficiency may contribute to some of the manifestations of obesity, diabetes, abnormal blood lipids, hypertension and coronary artery disease in 20th century western society.

Although some of the above is speculative, it would seem prudent for Americans to supplement their diets with small amounts of trivalent chromium (for example, 200 mcg of chromium picolinate) since the benefits of supplementation may be significant for certain individuals and the safety of this regimen is well-supported by a large amount of data.

# Postscript: What do Doctors Think About This?

You may now be asking: Why haven’t I heard about this? Do my friends who are diabetics known about this? Does my doctor know anything about this? These are reasonable questions, and there are several issues involved in dealing with issues relating to the apparent lack of interest in chromium for diabetics.

·Doctors have traditionally shied away from techniques involving nutritional management of their patients.
·There is still no reliable way to test individuals for chromium status.
·The first few decades of chromium research was complicated by contamination of the food or tissues being examined by significant amounts of chromium from the environment (the use of stainless steel laboratory equipment, for example). This resulted in confusing and contradictory results from different research facilities. By the early 1980s, this problem was resolved, however
·The marketing of nutritional therapies to physicians and other health professionals is not nearly as extensive as pharmaceutical marketing; since profits from nutritional therapies are significantly smaller than those from pharmaceuticals, supplement manufacturers cannot justify the large capital outlays needed for the promotional and educational materials for physicians. In addition, representatives of drug manufacturers frequently call on physicians to present them with new research data and samples of their products. Direct mail and advertising are other means by which pharmaceutical manufacturers get important information about their products to doctors. The same promotional and educational budgets are not available in the nutritional area.

Copyright: The Chromium Information Bureau, Inc. March, 1966; revised, June, 1996 and November, 1996

Permission is granted to reproduce this information.

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Robert Sarver has performed his own research into the claims regarding iodine and iodide made by Dr. Brownstein and Dr. Abraham. These are Mr. Sarver’s independent findings.
Iodine Deficiency Copyright 2005 By Robert Sarver, Permission to published granted to the Vitamin C Foundation

Dr. David Brownstein has a US medical practice dealing primarily with thyroid patients. He has been quite successful treating hypothyroidism and hyperthyroidism with the iodine/iodide supplement Iodoral that is available over the Internet without prescription. Dr. Brownstein believes that the usual thyroid medication prescribed by doctors is the wrong treatment because it does not deal with the underlying iodine deficiency problem.

All cells in the body need iodine for proper functioning. All glands (thyroid, adrenal, etc.) especially need iodine for the production of hormones. Dr. Brownstein believes that iodine deficiency is a major cause of breast cancer and other diseases of the reproductive organs such as ovarian, uterus and prostrate cysts and cancers. Iodine levels in US soil have fallen 50 per cent over the past 50 years and soil in the US is deficient in iodine. The Great Lakes region has some of lowest soil iodine levels in the world and this results in high levels of cancers related to iodine deficiency. Dr. Brownstein has been quite successful in treating fibrocystic breast disease (cysts in the breast) with iodine/iodine supplementation. In one case a 37 year-old woman with severe fibrocystic breast disease was completely cured after supplementing with 50 mgs of iodine a day for two months. Women with larger breasts need more iodine than women with smaller breasts. Other medical authorities agree that iodine deficiency can lead to fibrocystic breast disease and/or ovarian cysts. [1] [2] [3]

Iodine can similarly reduce uterine fibroids and one of the first conventional medical treatments for severe fibroids was to paint the uterus with iodine. [4]

Some other medical conditions associated with iodine deficiency are goiters, Graves’ Disease, Hashimoto’s Disease, fatigue and impaired immune system function. Iodine deficiency during pregnancy can lead to miscarriages and reduced IQ in surviving offspring. [5]

The World Health Organization says that iodine deficiency is the largest single cause of mental retardation. Iodine also detoxifies the body by removing mercury, fluorides, chlorides, and bromides.

If iodine/iodide are so crucial in the body, why hasn’t there been more research studies published? Dr. Brownstein believes that because iodine cannot be patented there is no incentive for the drug companies to perform the research.

Iodized salt and the iodine supplements usually found in health food stores contain the iodide form of iodine. Dr. Brownstein has had little success treating patients with only iodide. The supplement Iodoral contains both the iodide (reduced) and iodine (oxidized) forms of iodine because the body needs both forms. The US RDA for iodine is 150 mcg. Iodoral contains 100 times (12.5 mgs) the RDA’s requirement of iodine/iodide.

It seems the conventional medical establishment again has grossly underestimated the amount of a nutrient needed for good health. According to Dr. G. E. Abraham, “Of all the elements known so far to be essential for health, iodine is the most misunderstood and the most feared. Yet, it is by far the safest of all the trace elements known to be essential for human health. It is the only trace element that can be ingested safely in amounts up to 100,000 times the RDA. For example, potassium iodide has been prescribed safely to pulmonary patients in daily amounts of up to 6.0 gm/day, in large groups of such patients for several years. It is important however to emphasize that this safety record only applies to inorganic nonradioactive iodine/iodide, not to organic iodine-containing drugs and to radioiodides.” [6]

Seafood and sea plants such as kelp (seaweed) are good dietary sources of iodine but few people in the US consume enough of these foods. On a personal note, I found sellers of Iodoral on the Internet and purchased 180 tablets for $40. The usual dosage as a supplement is one tablet a da y but up to four tablets a day can be taken for medical conditions under a knowledgeable MD’s supervision.

For those interested in knowing more about iodine’s function in preventing and treating diseases, four of Dr. Brownstein’s video clips located at . . Dr. Brownstein’s home page and links to his books are located at .

His books include Iodine: Why You Need It, Why You Can’t Live Without It , Overcoming Thyroid Disorders and Salt: Your Way to Health which encourages consumption of sea salt in order to obtain many trace minerals.

# Informative research papers about iodine are at .

Iodine deficiency may be a major contributor to the widespread arthritis problems in the US. A home remedy for arthritis is consumption of two drops of Lugol’s solution each day. Two drops of Lugol’s solution contain thesame amount of iodine as one Iodoral tablet. Lugol’s solution is a water solution of 10 per cent potassium iodide and 5 per cent iodine.

Hormones control body weight. Malfunctioning glandular systems due to iodine deficiency may be a major cause of the overweight problem in the US.

# References:

[1] J. D. Fleches, MD,
[2] Abraham, G. E., Flechas, J. D., Hakala, J. C., Orthoiodosupplementation: Iodine sufficiency of the whole human body ,
[3] James Howenstine, MD, Iodine is vital for good health
[4] Herb and Supplement Encyclopedia,
[5] Iodine Deficiency Disorder,
[6] G. E. Abraham, MD, The safe and effective implementation of orthoiodosupplementation in medical practice.

# Further Resources

– Alan R. Gaby, MD’s Response to: A Rebuttal of Dr. Gaby’s Editorial on Iodine, and Letter to the Townsend Letter Editor: A Rebuttal of Dr. Gaby’s Editorial on Iodine

– Editorial Iodine: A Lot to Swallow”

– Evidence that the administration of Vitamin C improves a defective cellular transport mechanism for iodine

– Vitamin C Foundation home page


## Selenium and Fat Metabolism,

Nutrition Research News , Jl. Clin. Invest. July 15, 1996

DARTMOUTH: Selenium has a crucial role in controlling the effects of thyroid hormone on fat metabolism, report researchers at Dartmouth Medical School.

A new study published in the July 15, 1996 issue of The Journal of Clinical Investigation, underscores the importance of nutrition in thyroid hormone function. The researchers report that the key enzyme responsible for activating thyroid hormone in the brain and in brown fat, a heat-producing type of fat tissue, contains the rare amino acid selenocysteine that is formed in the body using dietary selenium. High amounts of selenium are present in such foods as beef, bread, poultry and seafood.

Thyroid hormone, which is produced in the thyroid gland using iodine, another nutritional element, influences several important body functions. These include fat metabolism in adults, and energy production and brain development in the fetus and newborn. In addition, patients with thyroid diseases often have difficulties with memory and mood changes.

However, before thyroid hormone can exert its effects, it must be activated. This occurs when specialized enzymes in various tissues remove an iodine atom from the hormone. Selenium appears to play an essential role in this process because of its unique ability to act as a strong catalyst and spur the activating reaction.

Although selenium had previously been shown to help activate thyroid hormone in the liver and kidney, its role in the function of the brain and brown fat enzyme had been controversial.

The Selenium Forum provides information to nutrition researchers, health care providers, media and consumers on the functions, actions and clinical effects of dietary selenium.
Questions or comments?:

Selenium Forum Web Page
© 1996 Selenium Forum

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## Manganese alters mitochodrial integrity in the hearts of swine marginally deficient in magnesium.,

Miller KB, Newman SM Jr, Caton JS, Finley JW.

Department of Animal and Range Science, North Dakota State University, Fargo, ND 58105, USA.

It was previously reported that pigs marginally deficient in magnesium (Mg) and fed diets high in manganese (Mn) died suddenly with signs of sudden cardiac death. Manganese, which has properties similar to Mg, may exacerbate Mg-deficiency and be accumulated by mitochondria resulting in ultrastructural damage. The objective of this study was to determine whether deaths of the type previously observed were mediated by adverse interactions of Mn and Mg resulting in ultrastructural damage to the myocardium, alterations in electrocardiographic recordings and tissue retention of Mn, Mg and calcium (Ca). Forty-eight pigs were fed one of six diets in a 2 X 3 factorial arrangement of Mg (100 or 1000 mg Mg/kg) and Mn (5, 50 or 500 mg Mn/kg) for 8 weeks. Left ventricle muscle samples were collected for examination by transmission electron microscopy. No differences in heart muscle ultrastructure were observed between pigs fed low and adequate dietary Mg. However, marked myocardial necrosis and mitochondrial swelling were observed in pigs fed high dietary Mn when combined with low Mg. Feeding low dietary Mg elevated minimum (P Low dietary Mg resulted in a 55% probability of a ventricular beat being recorded (P = 0.05) and lower Mg (P
These results suggest that high Mn, when fed in combination with low Mg, disrupts mitochondrial ultrastructure and is associated with the sudden deaths previously reported.

PMID: 15322332 [PubMed – indexed for MEDLINE]

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