- Coenzyme Q10 is an essential biomolecule that functions in the production of biochemical energy in aerobic organisms.
- Coenzyme Q10 is an essential electron and proton carrier.
- Coenzyme Q10 has properties that stabilize membranes.
- Coenzyme Q10 also contains antioxidant that prevents damage to cells due to normal metabolic processes.
- Coenzyme Q10 is made up of carbon, hydrogen and oxygen and its formula is C59H90O4.
- Coenzyme Q10 consists of quinone ring attached to an isoprene side chain.
- All mammalian tissues produce Coenzyme Q10.
COQ10 for CANCER from NCI
Coenzyme Q10 (PDQ®)–Patient Version Coenzyme Q10 is naturally made by the body and can be taken as a pill or injection. Studies have shown it to help protect from the damaging side effects of doxorubicin and to stimulate the immune system in cancer patients. Read about the results of clinical trials in cancer patients using coenzyme Q10 in this expert-reviewed summary.
Coenzyme Q10 (PDQ®)–Health Professional Version Coenzyme Q10 is a dietary supplement, and use of it as a treatment for cancer in humans has been investigated in only a limited manner. Get detailed information about Coenzyme Q10 use in cancer in this summary for clinicians.
Coenzyme Q10 is a vitamin-like fat-soluble antioxidant found everywhere in the body; the highest concentrations have been measured in vital organs such as the heart and pancreas. At age 20, the heart has a higher CoQ10 level than other major organs. At age 80 this is no longer true, with the heart levels cut by more than half.More than 35 controlled clinical trials in Japan, Europe and the U.S. have proven that CoQ10 therapy is highly effective in treatment of congestive heart failure, angina and ischemic heart disease, and myocardial infarction.
It is now believed that CoQ10 is the key nutrient for generating 95 percent of the total energy required by the human body.
A healthy, youthful human body can make its own CoQ10. Endogenous production or biosynthesis of CoQ10 has 17 steps, requiring at least seven vitamins (vitamin B2 – riboflavin, vitamin B3 – niacinamide, vitamin B6, folic acid, vitamin B12, vitamin C, and pantothenic acid) and several trace elements.
The pharmaceutical giant Merck has known for more than 15 years that statin drugs interfere with CoQ10 biosynthesis; leading to low serum levels which cause muscles to atrophy.The following claim from one of two 1990 Merck patents (4,933,165) is to add CoQ10 to statin drugs in order to overcome statin induced myopathy:
1. A pharmaceutical composition comprising a pharmaceutical carrier and an effective antihypercholesterolemic amount of an HMG-CoA reductase inhibitor and an amount of Coenzyme Q.sub.10 effective to counteract HMG-CoA reductase inhibitor-associated skeletal muscle myopathy.
This invention has never been implemented, probably because the entire world supply of CoQ10 is limited and current production would only supply one-sixth of the world’s statin users.
VARIOUS HEALTH BENEFITS ATTRIBUTED TO COQ10
The CoQ10 science has accelerated from its discovery in 1957 until the present day and appears excellent. [*] The following headlines summarize the many clinical studies that have shown CoQ10 supplementation beneficial in disease conditions ranging from Parkinson’s disease to cataracts.Dosages studied range from 30 mg to 1200 mg daily.Higher dosages have generally been found to be more beneficial.
– CoQ10 gives complete protection against stroke
Since 1972, in studies of stroke in three animal models (dog, rat, gerbil) ubiquinone (coq10) was the only agent giving complete protection and this was over two times more often than the next best agent (naloxone) of the many tested to date. [*]
– CoQ10 benefits Cardiovascular Disease
CoQ10 levels in heart tissue decline disproportionately with age. CoQ10 pioneer Karl Folkers (1985), in agreement with earlier Japanese studies, found lower CoQ10 levels in patients with more severe heart disease and showed that CoQ10 supplements significantly raised blood and heart tissue levels of CoQ10 in these patients. [*]
– CoQ10 improves high blood pressure
” At least six clinical trials have shown a blood pressure-lowering effect of CoQ10. [*]
– CoQ10 for Parkinson’s disease.
“Less disability developed in subjects on CoQ10 than in those on placebo, and the benefit was greatest in people receiving the highest dosage.” [*]
– CoQ10 benefits people with kidney failure.
” Because CoQ10 has the potential to revolutionize the treatment of chronic renal failure, a large-scale, long-term study should be initiated as soon as possible.” – Alan Gaby [*]
– CoQ10 for youthful skin
” Just recently scientists have also discovered that this natural supplement may even slow down the skin’s aging process. Gerson Unna confirmed that, like vitamin E, Co-Q10 slows down tissue damage by decreasing the effect of free radical molecules. In a placebo-controlled study, researchers at Beiersdorf discovered that after six weeks of daily treatment on crow’s feet (eye wrinkles), wrinkle depth was reduced by 27 percent; after 10 weeks, fine lines and wrinkles were reduced by a surprising 43 percent. The enzyme also has been effective in the reduction and fading of age spots and is touted by Beiersdorf for its lack of toxicity. [*]
– CoQ10 Effective for Migraine Prevention [*]
– CoQ10 Therapy can improve glucose control in Type 2 diabetics [*]
– 400 mg CoQ10 reportedly induced cancer remissions. [*]
Science has uncovered even more benefits of supplemental CoQ10. [*]
COQ10 SUPPLEMENTATION IS NECESSARY AS WE AGE
Researcher Dr. John Ely, of the University of Washington, holds that CoQ10 supplementation is essential in the aged.Most people make approximately 500 mg of Coq10 daily in the body, at least up until age 21. Between ages 21 and 30, levels of CoQ10 begin to drop, perhaps because of aging. This causes the degeneration of cells, which may contribute to age-related diseases and conditions such as high blood pressure, arthritis, heart disease and the breakdown of skin tissue.
Statin drugs and deficiencies in several other vitamins also cause blood levels of CoQ10 to drop.
According to Dr. Ely,
“Possibly the most important details not reported previously are those related to CoQ10 body pool and turnover rate that mandate human supplementation. Adult human body pool has been found to be approximately 2 grams and requires replacement of about 0.5 grams/day based on its average turnover rate of about 4 days in various tissues. This must be supplied either by endogenous synthesis or from exogenous sources. Synthesis decreases progressively in humans above age 21. Furthermore, the average ubiquinone content of the western diet is less than 5 mg/day. Thus, ubiquinone supplementation appears to be the only way for older people, and certainly the ill, to obtain the major proportion of the 0.5 gram/day need. Failure to supplement by the aged, ill or stressed, can have tragic consequences in the form of irreversible damage in the brain, other organs and mitochondria everywhere.”[ http://faculty.washington.edu/ely/turnover.htm].
CoQ10 pioneer Karl Folkers claimed that the primary source of CoQ10 in man is biosynthesis. Folkers argues that” suboptimal nutrient intake in man is almost universal causing subsequent secondary impairment in CoQ10 biosynthesis.” According to CoQ10 expert Peter H. Langsjoen, MD. “This means that average or “normal” levels of CoQ10 are really suboptimal and the very low levels observed in advanced disease states represent only the tip of a deficiency ice berg.“
The Vitamin C Connection
Vitamin C is a “natural” HMG-CoA reductase inhibitor. [*] It was observed experimentally that when vitamin C levels are low, cholesterol becomes elevated, and when more vitamin C is consumed, cholesterol levels decline.The mechanism by which vitamin C lowers cholesterol was discovered circa 1985. High Vitamin C levels inhibit the same the HMG-CoA Reductase enzyme as the statin drugs. The inescapable conclusion is that vitamin C does what statins do – lowers cholesterol — without side-effects.If the statin drugs were patterned after Vitamin C, they lack many other benefits of the vitamin. For example, vitamin C promotes the production of coenzyme Q10 and lowers Lp(a).
It is interesting that in addition to vitamin C, our bodies require many B vitamins to synthesize CoQ10. Voluminous research has found beneficial effects from ascorbic acid supplementation similar to the effects found from smaller dose CoQ10 supplementation. For example, in a recent study, hydro soluble CoQ10 supplementation was shown to lower circulating levels of Lp(a). We speculate that some of these similar effects may be due to increased endogenous CoQ10 synthesis induced by the ascorbic acid along with generally better all around nutrition.
Every human body makes up to 500 mg of CoQ10 daily; no human body can make vitamin C.As important as CoQ10 is for health, vitamin C is more important, perhaps an order of magnitude. That fact is that most mammals synthesize ten times more vitamin C than they do CoQ10, when adjusted for body weight.Under normal circumstances the daily amount of ascorbic acid produced by mammals lies between 3,000 mg and 15,000 mg, with an average of 5,400 mg, when adjusted for comparison to the weight of the average male human being.
We conclude that everyone should supplement 3,000 mg to 6,000mg vitamin C daily from birth, including during pregnancy. On the other hand, healthy, well-nourished children will usually synthesize their own CoQ10. With the possible exception of athletes, persons taking vitamin C should not have to supplement CoQ10 until the fourth or fifth decade of life. Athletes have a high requirement for CoQ10 and may benefit from supplementation earlier in life.
According Dr. Langsjoen,”The resulting lowering of blood CoQ10 level is due to the partially shared biosynthetic pathway of CoQ10 and cholesterol. In patients with heart failure this is more than a laboratory observation. It has a significant harmful effect which can be negated by oral CoQ10 supplementation.”
Dre Hulda Regehr Clark and CoQ10
(1928 – 2009) was a Canadian naturopath, author, and practitioner of alternative medicine. Clark wrote several books describing her methods and operated clinics in the United States.
Hulda clark’s protocol on the use of CQ10 in massive quantities in her book “The Cure For All Cancers”
French edition :
La Cure de tous les cancers – Hulda Clark
Livre de 633 pages avec de nombreux tableaux et illustrations. Edition française du livre original “The Cure for all cancers” du Dr Hulda Clark. Editeur: Dr Clark Reaserch Association (DCRA) Un livre vital depuis longtemps attendu, en français aussi…! https://www.vivrenaturellement.com/livres-dvd/1521-la-cure-de-tous-les-cancers-hulda-clark.html
Présentation : Cet ouvrage présente plus de 100 cas de personnes guéries du cancer. Il présente également deux appareils électroniques révolutionnaires: le premier diagnostique la maladie et suit l’évolution des progrès du malade, le deuxième élimine les parasites et les bactéries.
Présentation du livre par l’auteur : “Il est maintenant possible de guérir le cancer, pas seulement de le traiter. Nous n’avons pas l’habitude d’envisager la guérison du cancer. La rémission nous paraît représenter la seule issue possible. Mais ce livre ne parle pas de rémission. Il présente une façon de guérir le cancer. Cela est possible parce qu’en 1990 j’ai découvert la véritable cause du cancer. Le cancer est dû à un certain parasite, dont j’ai trouvé la trace chez tous les cancéreux, quel que soit leur type de cancer. Le cancer du poumon n’est donc pas imputable au tabac; le cancer du côlon n’est pas dû à une alimentation trop pauvre en aliments de lest; le cancer du sein ne provient pas d’une alimentation trop grasse; le blastome rétinien n’est pas causé par un gène rare, et la consommation d’alcool n’est pas responsable du cancer du pancréas.
Même si tous constituent des facteurs qui favorisent la maladie, ils n’en sont pas la cause. Une fois découverte la cause du cancer, le traitement devenait évident. Mais serait-il efficace?
Je me fixai alors un objectif: guérir 100 cas de cancer avant de publier le fruit de mes découvertes. Ce nombre fut dépassé en décembre 1992. La découverte de la cause et de la guérison de tous les cancers a supporté l’épreuve du temps et je vous en fais part; la voici!”
Dans “Espoir pour l’avenir”, à la fin, elle ajoute : “La seule raison qui me pousse à publier ce livre et à ne pas faire breveter les nouveaux appareils que je présente dans ces pages, c’est que je souhaite promouvoir l’autogestion de la Santé [“Self Health”]. Cette autogestion signifie la liberté en matière de santé – non seulement la liberté de consulter les praticiens officiels (les médecins) mais aussi celle de recourir (…) à des conseillers en santé, des chercheurs, des techniciens, et d’autres thérapeutes. Cela signifie la liberté de choisir et de demander ses propres analyses et d’en recevoir soi-même les résultats.”
Un livre très simple, très clair et très facile à lire et à comprendre, et qui, aussi à titre préventif, concerne, en fait, tout le monde. Car, une fois la cause biologique clairement reconnue il est tout à fait possible d’éliminer la cause par avance.